Recommended subdomain multisite nginx vhost configuration with new web/ layout

I see your point re: / I was trying to reconcile the following line in the htaccess that worked for me:

RewriteRule ^(.*\.php)$ wp/$1 [L]

I guess the primary thing that’s left to contend with is this line:

RewriteRule ^(wp-(content|admin|includes).*) wp/$1 [L]

Isn’t that rewrite something that any of the installations has to deal with, even if not multisite? I really apologize for my ignorance in the realm of nginx. I usually rely on htaccess files to control it all, but read in a few locations where you guys relied on nginx and put everything in the vhost configuration so you didn’t have to worry about replicating the environments and symlinking the htaccess files.