It shouldn’t, no. Any changes should be minor, and likely confined to external packages, i.e. Acorn. The only major change that I’m aware of that’s still waiting to land is switching out mix for bud: Replace Laravel Mix with Bud by kellymears · Pull Request #2643 · roots/sage · GitHub That’s build-tooling though, so depending on your needs it may not matter.
Until we’ve officially tagged a release, though, it is technically still in development. Generally
dev-master works (I’ve built several production sites on in-progress versions of Sage 10) so you can always build a site off it, but things can still change. Then again, we’ve moved a lot of Sage into dependent packages, which in theory makes future updates easier.